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A combination of serotonin receptor 5-hydroxytryptamine receptor type 3 antagonists, NK-1 receptor antagonist, and steroid improves the complete response CR of chemotherapy-induced nausea and vomiting CINV in cancer patients. This prospective, multicenter, single-blind, randomized, phase III study compares a combination of ramosetron, aprepitant, and dexamethasone RAD with a combination of ondansetron, aprepitant, and dexamethasone OAD to prove the noninferiority of RAD in controlling highly emetogenic CINV.
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