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Aprepitant has little or no affinity for serotonin 5-HT3 , dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting CI NV. For the prevention of nausea and...

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[Full text] The impact of 5-hydroxytryptamine-receptor antagonists on chemotherapy | CMAR -

A combination of serotonin receptor 5-hydroxytryptamine receptor type 3 antagonists, NK-1 receptor antagonist, and steroid improves the complete response CR of chemotherapy-induced nausea and vomiting CINV in cancer patients. This prospective, multicenter, single-blind, randomized, phase III study compares a combination of ramosetron, aprepitant, and dexamethasone RAD with a combination of ondansetron, aprepitant, and dexamethasone OAD to prove the noninferiority of RAD in controlling highly emetogenic CINV.

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Ergoloid mesylate The metabolism of Aprepitant can be decreased when combined with Ergoloid mesylate. Chlorpromazine The metabolism of Aprepitant can be decreased when combined with Chlorpromazine. Bupropion The metabolism of Aprepitant can be decreased when combined with Bupropion.

Aknyzeo netupitant and palonosetron capsules, for oral use and fosnetupitant and palonosetron for injection [prescribing information]. Medrogestone The metabolism of Aprepitant can be decreased when combined with Medrogestone. Salbutamol The metabolism of Aprepitant can be decreased when combined with Salbutamol.

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